Skip to content

A Bayesian hierarchical model for the mechanistic prediction of developmental neurotoxicity

Notifications You must be signed in to change notification settings

nicospinu/bayesian-dnt

Folders and files

NameName
Last commit message
Last commit date

Latest commit

 

History

55 Commits
 
 
 
 
 
 
 
 
 
 
 
 

Repository files navigation

Bayesian modelling of developmental neurotoxicity

About this repository

It includes the electronic materials, i.e., the scripts and data used to train the model. The model predicted the probability that a compound induces each of three selected common key events (CKEs) of the simplified Adverse Outcome Pathway (AOP) network and the adverse outcome (AO) of developmental neurotoxicity (DNT), taking into account correlations and causal relations informed by the key event relationships (KERs). It can be run on Binder

The conceptual framework

The reference

The publication on this work can be read here https://doi.org/10.1016/j.comtox.2021.100206

Available video

The results were initially presented at the PyMCon2020 Conference.